Regional rankings from Week One (April 26, 2018)
Schools that have earned an automatic bid are in bold. Schools that are in in Pool B are in italics. La Grange (USA South) and Willamette (NWC) have their conference bids and are not regionally ranked.
| Rank | School | vs. D-III | Overall |
| Central | |||
| 1 | North Central (Ill.) | 17-8 | 17-8 |
| 2 | Carthage | 23-5 | 24-6 |
| 3 | Webster | 24-7 | 24-7 |
| 4 | Coe | 16-9 | 17-10 |
| 5 | Wartburg | 17-9 | 17-9 |
| 6 | Illinois Wesleyan | 18-12 | 18-12 |
| 7 | Washington U. | 17-14 | 17-14 |
| 8 | St. Norbert | 16-8 | 16-8 |
| Mid-Atlantic | |||
| 1 | Rowan | 25-6 | 25-6 |
| 2 | TCNJ | 23-6 | 23-6 |
| 3 | Keystone | 22-7 | 22-7 |
| 4 | Arcadia | 23-10 | 23-10 |
| 5 | Alvernia | 25-10 | 25-10 |
| 6 | Ramapo | 23-11 | 23-11 |
| 7 | Misericordia | 23-10 | 23-10 |
| 8 | Rutgers-Camden | 20-12 | 20-12 |
| 9 | Johns Hopkins | 23-11 | 23-11 |
| 10 | Catholic | 25-9 | 25-9 |
| 11 | William Paterson | 21-10 | 21-10 |
| 12 | DeSales | 20-12 | 20-12 |
| Mideast | |||
| 1 | Case Western Reserve | 25-6 | 25-6 |
| 2 | Wooster | 25-4 | 25-4 |
| 3 | Adrian | 24-5 | 24-5 |
| 4 | Otterbein | 23-9 | 23-9 |
| 5 | Marietta | 22-9 | 22-9 |
| 6 | Baldwin Wallace | 23-9 | 23-9 |
| 7 | Washington & Jefferson | 21-9-1 | 21-10-1 |
| 8 | Heidelberg | 20-12 | 20-12 |
| 9 | La Roche | 23-6-1 | 23-6-1 |
| 10 | Denison | 22-7 | 22-7 |
| 11 | Franklin | 28-2 | 28-2 |
| 12 | Ohio Northern | 21-10 | 21-10 |
| 13 | Mount Union | 16-11 | 16-11 |
| Midwest | |||
| 1 | Concordia-Chicago | 20-7 | 20-8 |
| 2 | UW-Whitewater | 17-3 | 17-3 |
| 3 | UW-Oshkosh | 18-4 | 18-4 |
| 4 | UW-Stevens Point | 18-5 | 18-5 |
| 5 | Bethel | 17-5 | 17-5 |
| 6 | Aurora | 19-9 | 19-9 |
| 7 | UW-La Crosse | 14-9 | 14-9 |
| 8 | Benedictine | 15-8 | 15-8 |
| New England | |||
| 1 | Mass-Boston | 26-5 | 26-5 |
| 2 | Southern Maine | 20-8 | 20-8 |
| 3 | Babson | 25-10 | 25-10 |
| 4 | Endicott | 18-11 | 18-11 |
| 5 | Mass-Dartmouth | 17-11 | 17-11 |
| 6 | Western New England | 22-10 | 22-10 |
| 7 | Salve Regina | 16-11 | 16-11 |
| 8 | Wheaton (Mass.) | 19-13 | 19-13 |
| 9 | MIT | 15-11 | 15-11 |
| 10 | Clark | 21-10 | 21-10 |
| 11 | Rhode Island College | 17-10 | 17-10 |
| 12 | Eastern Connecticut | 15-10 | 16-10 |
| 13 | Springfield | 20-11-2 | 20-11-2 |
| 14 | Amherst | 16-8 | 17-8 |
| New York | |||
| 1 | St. John Fisher | 21-9 | 21-9 |
| 2 | Cortland | 28-7 | 28-7 |
| 3 | Oswego State | 21-8 | 21-8 |
| 4 | Stevens | 20-14 | 20-14 |
| 5 | Union | 21-6 | 21-6 |
| 6 | Ithaca | 16-12 | 16-12 |
| 7 | New York University | 25-8 | 25-8 |
| 8 | St. Joseph's (L.I.) | 18-14 | 18-14 |
| 9 | Farmingdale State | 20-11 | 20-11 |
| South | |||
| 1 | Randolph-Macon | 26-4-1 | 26-4-1 |
| 2 | Christopher Newport | 29-7 | 29-7 |
| 3 | Salisbury | 25-9 | 25-9 |
| 4 | Virginia Wesleyan | 24-10 | 24-10 |
| 5 | Berry | 28-11 | 28-11 |
| 6 | Piedmont | 26-12 | 28-12 |
| 7 | Rhodes | 25-12 | 27-13 |
| 8 | Methodist | 28-10 | 30-11 |
| 9 | Roanoke | 26-8 | 26-8 |
| West | |||
| 1 | Trinity (Texas) | 28-4 | 31-4 |
| 2 | Redlands | 28-9 | 28-9 |
| 3 | Chapman | 27-10 | 27-10 |
| 4 | Concordia (Texas) | 25-12 | 25-12 |
| 5 | Texas Lutheran | 28-9 | 28-9 |
| 6 | La Verne | 25-12 | 25-12 |
| 7 | Texas-Tyler | 23-13 | 23-13 |
| 8 | Cal Lutheran | 21-16 | 21-16 |